African scientists baffled by cases of monkeypox in Europe and the United States

African scientists baffled by cases of monkeypox in Europe and the United States
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LONDON — Scientists who have tracked numerous outbreaks of monkeypox in Africa say they are baffled by the disease’s recent spread to Europe and North America.

Cases of the smallpox-related disease have previously only been seen among people with links to West and Central Africa. But over the past week, Britain, Spain, Portugal, Italy, the United States, Sweden and Canada have all reported infections, mostly in young men who had never traveled to Africa before.

There are around 80 confirmed cases worldwide and another 50 suspected cases, the World Health Organization said. France, Germany, Belgium and Australia reported their first cases on Friday.

“I am stunned by this. Every day I wake up and there are more countries infected,” said Oyewale Tomori, a virologist who previously headed the Nigerian Academy of Sciences and sits on several WHO advisory boards.

“This is not the kind of spread we have seen in West Africa, so there may be something new happening in the West,” he said.

To date, no one has died in the outbreak. Monkeypox usually causes fever, chills, rashes, and sores on the face or genitals. The WHO estimates the disease is fatal for up to one in 10 people, but smallpox vaccines are protective and some antiviral drugs are in development.

Nigeria reports around 3,000 cases of monkeypox a year, the WHO said. Outbreaks usually occur in rural areas, when people come into close contact with infected rats and squirrels, Tomori said. He said many cases are likely missed.

Dr Ifedayo Adetifa, head of the country’s Center for Disease Control, said none of the UK patients’ Nigerian contacts had developed symptoms and investigations were ongoing.

WHO director for Europe Dr Hans Kluge described the outbreak as “atypical”, saying the occurrence of the disease in so many countries across the continent suggested that “transmission has been going on for some time”. He said most European cases are mild.

The UK health security agency reported 11 new cases of monkeypox on Friday, saying a “notable proportion” of infections in the UK and Europe were in young men with no history of travel to Africa and who were gay, bisexual or had sex with men. .

Experts have stressed that they do not know whether the disease is spread through sex or through other close sex-related contacts.

Nigeria has not experienced sexual transmission, Tomori said, but he noted that viruses that were not initially known to be sexually transmitted, such as Ebola, were later found to do so after more large epidemics have shown different patterns of spread.

The same could be true for monkeypox, Tomori said.

In Germany, Health Minister Karl Lauterbach said the government was confident the outbreak could be contained. He said the virus was being sequenced to see if there were any genetic changes that could have made it more infectious.

Rolf Gustafson, a professor of infectious diseases, told Swedish broadcaster SVT it was “very difficult” to imagine the situation could get worse.

“We will definitely find more cases in Sweden, but I don’t think there will be an outbreak in any way,” Gustafson said. “Nothing suggests it at the moment.”

Scientists have said that while it is possible that the first patient in the outbreak caught the disease in Africa, what is happening now is exceptional.

“We have never seen anything like this happening in Europe,” said Christian Happi, director of the African Center of Excellence for Genomics of Infectious Diseases. “We have seen nothing to indicate that the transmission patterns of monkeypox have changed in Africa. So if something different is happening in Europe, then Europe needs to investigate it.

Happi also pointed out that the suspension of smallpox vaccination campaigns after the disease was eradicated in 1980 could inadvertently contribute to the spread of monkeypox. Smallpox vaccines also protect against monkeypox, but mass vaccination was stopped decades ago.

“Apart from people in West and Central Africa who may have some immunity to monkeypox from past exposure, lack of smallpox vaccination means no one has any sort of immunity to monkeypox,” Happi said.

Shabir Mahdi, professor of vaccinology at the University of the Witwatersrand in Johannesburg, said a detailed investigation of the outbreak in Europe, including determining who the first patients were, was now essential.

“We really need to understand how it started and why the virus is now gaining traction,” he said. “In Africa, there have been very controlled and infrequent outbreaks of monkeypox. If this is changing, we really need to understand why.


Geir Moulson in Berlin, Jan M. Olsen in Copenhagen, Chinedu Asadu in Lagos, Nigeria, and AP journalists across Europe contributed to this report.


The Associated Press Health and Science Department is supported by the Howard Hughes Medical Institute Department of Science Education. The AP is solely responsible for all content.

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