Health

People with high levels of omega-3 DHA in their blood have a 49% lower risk of developing Alzheimer’s disease – Neuroscience News

Neuroscience News logo for mobile.
Written by admin_3fxxacau

Summary: People with high levels of omega-3 DHA in their blood are 49% less likely to develop dementia than those with lower levels. Researchers say adding supplemental omega-3 DHA to the diet, especially in people with the Apoe4 gene associated with Alzheimer’s disease, may slow the development and progression of dementia.

Source: Wright on Marketing and Communications

A new study published today in Nutrients shows that people with high levels of DHA in their blood are 49% less likely to develop Alzheimer’s disease compared to those with lower levels, according to the Fatty Acid Research Institute (FARI).

The study, led by Aleix Sala-Vila, PhD, suggested that supplemental dietary intake of omega-3 DHA, particularly for those who carry the ApoE4 gene (which approximately doubles an individual’s susceptibility to developing the MA) could slow the development of the disease.

Such a cost-effective, low-risk dietary intervention like this could potentially save billions in healthcare costs.

In this prospective observational study conducted within the Framingham Offspring Cohort – comprising 1490 participants without dementia aged ≥ 65 years – researchers examined the association of red blood cell (RBC) docosahexaenoic acid (DHA) with the disease of Alzheimer’s disease (AD), while testing an interaction with the transporter APOE-ε4.

The risk of AD incident in the highest quintile of erythrocyte DHA (Q5, >6.1%) was 49% lower than in the lowest quintile (Q1, <3.8%). It was predicted that an increase in erythrocyte DHA from the first to the fifth trimester would provide about 4.7 additional years of life without Alzheimer's disease.

Additionally, the researchers noted that increased intake of DHA may reduce the risk of developing Alzheimer’s disease, particularly in high-risk individuals such as those carrying the APOE-ε4 allele, suggesting that ‘they might benefit more from higher DHA levels than non-carriers.

The public health impact of preventing AD with something as simple as a dietary intervention like DHA is also significant.

The researchers noted that “given that the estimated health care payments in 2021 for all patients with Alzheimer’s disease or other dementias amount to $355 billion in the United States (not including care provided by family members and other unpaid caregivers), any cost-effective strategy to delay the onset of Alzheimer’s disease is of major public health interest”, and that “delaying the disease 5 years of Alzheimer’s disease leads to 2.7 additional years of life and 4.8 additional years without Alzheimer’s disease for a person who has contracted Alzheimer’s disease and is worth more than 500,000 dollars”.

It was predicted that an increase in erythrocyte DHA from the first to the fifth trimester would provide about 4.7 additional years of life without Alzheimer’s disease. Image is in public domain

So how does this document compare to others in this area? “Our study is in line with that of Tan et al. who reported cross-sectional associations with RBC DHA on cognitive performance and measures of brain volume (higher DHA being associated with beneficial outcomes) in the same cohort studied here,” said William S. Harris, PhD , president of FARI and lead author on this recent study.

See also

This shows the dna

“More interestingly, 15 years ago, similar findings were reported by Schaefer et al. in the parents of the individuals who were the subject of the present investigation (i.e. the cohort of the Framingham Heart Study).

“Schafer et al. reported that participants in the top quartile of plasma DHA phosphatidylcholine had a significant 47% reduction in risk of developing dementia from all causes compared to those with lower levels,” Dr. Harris continued.

“Similar findings a generation apart in a similar gene pool provide considerable confirmation of this DHA-dementia relationship.”

About this Alzheimer’s disease research news

Author: Becky Wright
Source: Wright on Marketing and Communications
Contact: Becky Wright – Wright on Marketing and Communications
Image: Image is in public domain

Original research: The findings will appear in Nutrients

#People #high #levels #omega3 #DHA #blood #risk #developing #Alzheimers #disease #Neuroscience #News

About the author

admin_3fxxacau

Leave a Comment